Kalipada Pahan Selected Research

Gemfibrozil (Lopid)

10/2021	Gemfibrozil Protects Dopaminergic Neurons in a Mouse Model of Parkinson's Disease via PPARα-Dependent Astrocytic GDNF Pathway.
5/2019	Gemfibrozil, a Lipid-Lowering Drug, Lowers Amyloid Plaque Pathology and Enhances Memory in a Mouse Model of Alzheimer's Disease via Peroxisome Proliferator-Activated Receptor α.
1/2017	Safety and potential efficacy of gemfibrozil as a supportive treatment for children with late infantile neuronal ceroid lipofuscinosis and other lipid storage disorders.
1/2017	Gemfibrozil, food and drug administration-approved lipid-lowering drug, increases longevity in mouse model of late infantile neuronal ceroid lipofuscinosis.
11/2012	Gemfibrozil and fenofibrate, Food and Drug Administration-approved lipid-lowering drugs, up-regulate tripeptidyl-peptidase 1 in brain cells via peroxisome proliferator-activated receptor α: implications for late infantile Batten disease therapy.
10/2012	Gemfibrozil, a lipid-lowering drug, increases myelin genes in human oligodendrocytes via peroxisome proliferator-activated receptor-β.
8/2012	Gemfibrozil, a lipid-lowering drug, induces suppressor of cytokine signaling 3 in glial cells: implications for neurodegenerative disorders.
8/2012	Gemfibrozil, a lipid lowering drug, inhibits the activation of primary human microglia via peroxisome proliferator-activated receptor β.
1/2009	Gemfibrozil, stretching arms beyond lipid lowering.
10/2007	Gemfibrozil ameliorates relapsing-remitting experimental autoimmune encephalomyelitis independent of peroxisome proliferator-activated receptor-alpha.

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Kalipada Pahan Research Topics

Disease

26	Multiple Sclerosis 11/2018 - 10/2002
22	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2021 - 04/2003
21	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 05/2006
20	Parkinson Disease (Parkinson's Disease) 12/2021 - 11/2007
17	Inflammation (Inflammations) 10/2021 - 05/2006
15	Alzheimer Disease (Alzheimer's Disease) 12/2021 - 11/2008
10	Inborn Urea Cycle Disorders 12/2021 - 04/2003
10	Demyelinating Diseases (Demyelinating Disease) 11/2018 - 07/2006
8	Neuroinflammatory Diseases 05/2019 - 11/2002
5	Nonketotic Hyperglycinemia 12/2021 - 01/2020
5	Amyloid Plaque 05/2019 - 01/2014
4	COVID-19 12/2021 - 01/2020
4	Dementia (Dementias) 10/2021 - 09/2003
4	Autoimmune Diseases (Autoimmune Disease) 01/2021 - 10/2002
4	Neuronal Ceroid-Lipofuscinoses (Neuronal Ceroid Lipofuscinosis) 01/2019 - 11/2012
4	Disease Progression 05/2017 - 07/2007
3	Neoplasms (Cancer) 01/2022 - 02/2016
3	Pain (Aches) 01/2021 - 12/2013
3	Huntington Disease (Huntington's Disease) 01/2021 - 01/2016
3	Hyperlipidemias (Hyperlipidemia) 05/2019 - 10/2007
2	Synucleinopathies 12/2022 - 05/2019
2	Vesicular Stomatitis 12/2021 - 11/2021
2	Fever (Fevers) 12/2021 - 01/2021
2	Infections 01/2021 - 10/2017
2	Gliosis 05/2019 - 05/2006
2	Hyperammonemia 01/2019 - 03/2013
2	Chronic Disease (Chronic Diseases) 11/2018 - 05/2017
2	Virus Diseases (Viral Diseases) 06/2008 - 04/2004
1	Breast Neoplasms (Breast Cancer) 01/2022
1	Triple Negative Breast Neoplasms 01/2022
1	Brain Injuries (Brain Injury) 12/2021
1	Pneumonia (Pneumonitis) 12/2021
1	Coronary Disease (Coronary Heart Disease) 10/2021
1	Multiple System Atrophy 10/2021
1	Murine Acquired Immunodeficiency Syndrome (MAIDS) 01/2021
1	Acquired Immunodeficiency Syndrome (AIDS) 01/2021
1	Malaria 01/2020

Drug/Important Bio-Agent (IBA)

24	Pharmaceutical PreparationsIBA 12/2021 - 11/2002
13	Sodium Benzoate FDA Link 12/2021 - 07/2007
11	Gemfibrozil (Lopid)FDA LinkGeneric 10/2021 - 11/2002
9	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2021 - 06/2013
8	LipidsIBA 10/2021 - 10/2007
8	RNS60IBA 01/2020 - 01/2012
7	Peptides (Polypeptides)IBA 10/2021 - 07/2004
6	Interleukin-23 (Interleukin 23)IBA 01/2022 - 06/2008
6	Food Additives (Food Additive)IBA 01/2021 - 07/2007
6	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 11/2019 - 08/2012
6	Proteins (Proteins, Gene)FDA Link 02/2016 - 06/2012
5	Interleukin-12 (IL 12)IBA 01/2022 - 06/2008
5	Therapeutic UsesIBA 10/2021 - 11/2002
5	Amyloid (Amyloid Fibrils)IBA 05/2019 - 01/2014
5	Myelin Basic ProteinIBA 11/2018 - 09/2005
5	CytokinesIBA 08/2012 - 09/2005
4	Chemokine CCL5IBA 12/2019 - 01/2016
4	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 12/2019 - 11/2007
4	Biological ProductsIBA 02/2016 - 05/2006
4	Nitric Oxide (Nitrogen Monoxide)FDA Link 07/2013 - 07/2006
3	Angiotensin-Converting Enzyme 2IBA 12/2021 - 01/2021
3	cinnamic acidIBA 04/2019 - 01/2018
3	Tripeptidyl-Peptidase 1IBA 01/2019 - 11/2012
3	LigandsIBA 01/2019 - 03/2015
3	Amyloid beta-PeptidesIBA 01/2019 - 11/2008
3	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 07/2013 - 04/2004
3	4-phenylbutyric acid (Buphenyl)FDA Link 03/2013 - 04/2003
3	NF-kappa B (NF-kB)IBA 11/2007 - 11/2002
2	Fenofibrate (CiL)FDA LinkGeneric 12/2022 - 11/2012
2	Monoclonal AntibodiesIBA 01/2022 - 04/2009
2	Interleukin-12 Subunit p40IBA 01/2022 - 04/2009
2	Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA 10/2021 - 01/2019
2	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 01/2021 - 07/2012
2	EnzymesIBA 01/2019 - 01/2017
2	alpha-SynucleinIBA 02/2016 - 11/2013
2	Ciliary Neurotrophic Factor (CNTF)IBA 11/2015 - 06/2013
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 08/2015 - 06/2011
2	Simvastatin (Zocor)FDA LinkGeneric 08/2015 - 10/2009
2	Brain-Derived Neurotrophic Factor (BDNF)IBA 06/2013 - 03/2013
2	Nerve Growth Factors (Neurotrophins)IBA 06/2013 - 03/2013
2	Phosphotransferases (Kinase)IBA 09/2012 - 11/2007
2	Transcription Factors (Transcription Factor)IBA 09/2012 - 08/2012
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2012 - 09/2008
2	Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA 09/2010 - 06/2007
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/2009 - 09/2003
2	Double-Stranded RNA (RNA, Double Stranded)IBA 06/2008 - 04/2004
2	I-kappa B KinaseIBA 11/2007 - 07/2004
2	Drinking WaterIBA 07/2007 - 04/2003
2	AntigensIBA 06/2003 - 10/2002
1	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2022
1	EugenolIBA 12/2021
1	SynucleinsIBA 10/2021
1	HDL CholesterolIBA 10/2021
1	LDL CholesterolIBA 10/2021
1	Interleukin-6 (Interleukin 6)IBA 01/2021
1	Huntingtin ProteinIBA 01/2021
1	OccludinIBA 01/2020

Therapy/Procedure

15	Therapeutics 01/2022 - 12/2007
4	Oral Administration 05/2019 - 01/2015
3	Immunomodulation 01/2020 - 12/2011
1	Immunotherapy 01/2022
1	Neurosurgical Procedures 12/2021
1	Intranasal Administration 10/2021